Published Papers

 

Papers are organized by topic and by year of publication.  Click on the citation to read the abstract on PubMed (if indexed) or on the journal website.  Please email WorkingWithDepression@ubc.ca if you would like a .pdf version of an article.

 

*NEW:

• Yang T, Zhao G, Mao R, Huang J, Xu X, Su Y, Zhu N, Zhou R, Lin X, Xia W, Wang F, Liu R, Wang X, Huang Z, Wang Y, Hu Y, Cao L，Yuan C, Wang Z, Lam RW, Chen J. The association of duration and severity of disease with executive function: differences between drug-naïve patients with bipolar and unipolar depression. Journal of Affective Disorders 2018; 238:412-17.

• Morton E, Murray G, Michalak EE, Lam RW, Beaulieu S, Sharma V, Cervantes P, Parikh SV, Yatham LN. Quality of life in bipolar disorder: Towards a dynamic understanding. Psychological Medicine 2018; 48:1111-18.

• Blumberger DM, Vila-Rodriguez F, Thorpe K, Feffer K, Noda Y, Giacobbe P, Knyahnytska Y, Kennedy SH, Lam RW, Daskalakis ZJ, Downar J. Theta burst versus high frequency repetitive transcranial magnetic stimulation effectiveness evaluation in depression (THREE-D): a randomized non-inferiority trial. Lancet 2018; 391:1683-1692.

• Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, SharmaV, Goldstein BI, Rej S, Beaulieu S, Alda M, MacQueen G, Milev RV, Ravindran A, O’Donovan C, McIntosh D, Lam RW, Vazquez G, Kapczinski F, McIntyre RS, Kozicky J, Kanba S, Lafer B, Suppes T, Calabrese JR, Vieta E, Malhi G, Post RM, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) / International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disorders 2018; 20:97-170.

• Ng C, Goodenow MM, Greenshaw AJ, Upshall P, Lam RW. Inclusion of mental health in global economic development. BJPsych International, published online 21 March 2018.

• Cha DS, Carmona N, Subramaniapillai M, Mansur RB, Lee Y, Lee JH, Lee JG, Rosenblat JD, Shekotikhina M, Park C, Rong C, Greer TL, Lam R, Baune BT, Harrison JE, McIntyre RS. Cognitive impairment as measured by the THINC-integrated tool (THINC-it): Association with psychosocial function in major depressive disorder. Journal of Affective Disorders 2018; 222:14-20.

• McIntyre RS, Best MW, Bowie CR, Carmona NE, Cha DS, Lee Y, Subramaniapillai M, Mansur RB, Barry H, Baune BT, Culpepper L, Fossati P, Greer TL, Harmer C, Klag E, Lam RW, Wittchen HU, Harrison JE. The THINC-integrated tool (THINC-it) screening assessment for cognitive dysfunction: Validation in patients with major depressive disorder. Journal of Clinical Psychiatry 2017; 78:873-881.

• McIntyre RS, Florea I, Tonnoir B, Loft H, Lam RW, Christensen MC. Efficacy of vortioxetine on cognitive functioning in working patients with major depressive disorder. Journal of Clinical Psychiatry. 2017; 78:115-121.

• Lam RW, Kennedy SH, McIntyre RS, Khullar A: Cognitive dysfunction in major depressive disorder: Effects on psychosocial functioning and implications for treatment. Canadian Journal of Psychiatry 59(12):649-654 2014.

• Evans VC, Iverson GL, Yatham LN, Lam RW: The relationship between neurocognitive and psychosocial functioning in major depressive disorder: a systematic review. Journal of Clinical Psychiatry 2014.

• Evans VC, Chan SSL, Iverson GL, Bond DJ, Yatham LN, Lam RW: Systematic review of neurocognition and occupational functioning in major depressive disorder. Neuropsychiatry 3:97-105, 2013.

•  Iverson, GL, Lam, RW: Rapid screening for perceived cognitive impairment in major depressive disorder. Annals of Clinical Psychiatry 25:135-140, 2013.

Work and psychosocial functioning in Mood Disorders:

• Sarfati D, Stewart K, Woo C, Parikh SV, Yatham LN, Lam RW. The effect of remission status on work functioning in employed patients treated for major depressive disorder. Annals of Clinical Psychiatry. 2017; 29:11-16

• Evans VC, Alamian G, McLeod J, Woo C, Yatham LN, Lam RW.  The effects of newer antidepressants on occupational impairment in major depressive disorder: A systematic review and meta-analysis of randomized controlled trials. CNS Drugs 2016; 30:405-17.

• Lam RW, Iverson GL, Evans VC, Yatham LN, Stewart K, Tam EM, Axler A, Woo C. The effects of desvenlafaxine on neurocognitive and work functioning in employed outpatients with major depressive disorder. Journal of Affective Disorders 2016; 203:55-61. 

• Wang J, Lam RW, Ho K, et al. Preferred Features of E-Mental Health Programs for Prevention of Major Depression in Male Workers: Results From a Canadian National Survey. Journal of Medical Internet Research 2016; 18:e132.

• Lam RW, Parikh SV, Michalak EE, Dewa CS, Kennedy SH: Canadian Network for Mood and Anxiety Treatments (CANMAT) consensus recommendations for functional outcomes in major depressive disorder. Annals of Clinical Psychiatry 27(2) 2015.
• Chiu LYL, Stewart K, Woo C, Yatham L, Lam RW: The relationship between burnout and depressive symptoms in patients with depressive disorders. Journal of Affective Disorders 172:361–366, 2015.

• Lam RW, Endicott J, Hsu MA, Fayyad R, Guico-Pabia C, Boucher M: Predictors of functional improvement in employed adults with major depressive disorder treated with desvenlafaxine. International Clinical Psychopharmacology 29:239-251 2014.

• Lam RW, Parikh SV, Ramasubbu R, Michalak EE, Tam EM, Axler A, Yatham LN, Kennedy SH, Manjunath CV: Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder. British Journal of Psychiatry 203:358–365, 2013.

• Lam RW, Malhi GS, McIntyre RS, Demyttenaere K, Gorwood P, Michalak EE, Hegerl U: Fatigue and occupational functioning in major depressive disorder. Australian and New Zealand Journal of Psychiatry, May 2013.

•  Lam RW, McLeod J, Woo C, Michalak EE, Yatham LN, Bond DJ: A Systematic Review of the Treatment Effects of Antidepressants on Occupational Functioning. Poster presented to the International Society for Affective Disorders, 2012.

• Lam RW, Michalak EE, Solomons K, Tam EM, Axler A, Yatham LN: Which depressive symptoms and medication side effects are perceived by patients as interfering most with work functioning? Depression Research and Treatment, Article ID 630206, 2012.

• Lam RW, Filteau MJ, Milev R: Clinical effectiveness: The importance of psychosocial functioning outcomes. Journal of Affective Disorders 132:S9-S13, 2011.

• Kauer-Sant’Anna M, Bond DJ, Lam RW, Yatham LN: Functional outcomes in first-episode patients with bipolar disorder: a prospective study from the Systematic Treatment Optimization Program for Early Mania project.  Comprehensive Psychiatry 50:1-8, 2009.

• Michalak EE, Yatham LN, Maxwell V, Hale S, Lam RW: The impact of bipolar disorder upon work functioning: A qualitative analysis. Bipolar Disorders 9:126-43, 2007.

Quality of Life (QoL):

• Michalak EE, Torres IJ, Bond DJ, Lam RW, Yatham LN: The relationship between clinical outcomes and quality of life in first-episode mania: a longitudinal analysis. Bipolar Disorders 15:188–198, 2013.

• Michalak EE, Murray G, Young AH, Lam RW: Burden of Bipolar Depression: Impact of Disorder and Medications on Quality of Life. CNS Drugs 22:389-406, 2008.

•  Michalak EE, Murray G, Levitt AJ, Levitan RD, Enns MW, Morehouse R, Tam EM, Cheung A, Lam RW: Quality of life as an outcome indicator in patients with seasonal affective disorder: results from the Can-SAD study. Psychological Medicine 37:727-736, 2007.

• Michalak EE, Yatham LN, Kolesar S, Lam RW: Bipolar disorder and quality of life: A patient-centered perspective. Quality of Life Research 15:25-37, 2006.

• Michalak EE, Yatham LN, Lam RW: Quality of life in bipolar disorder: A review of the literature. Health and Quality of Life Outcomes: 3:72, 2005.

• Michalak EE, Tam EM, Manjunath CV, Solomons K, Levitt AJ, Levitan R, Enns M, Morehouse R, Yatham LN, Lam RW: Generic and health-related quality of life in patients with seasonal and nonseasonal depression. Psychiatry Research 128:245-251, 2004.

Employee Assistance Programs:

• Lam RW, Wolinsky D, Kinsella C, Woo C, Cayley PM, Walker AB: The Prevalence and Impact of Depression in Self-Referred Clients Attending an Employee Assistance Program. Journal of Occupational and Environmental Medicine 54:1395-1399, 2012.

• Lam RW, Lutz K, Preece M, Cayley P, Walker AB: Telephone administered cognitive behavioural therapy for clients with depressive symptoms in an Employee Assistance Program: A pilot study. Annals of Clinical Psychiatry 23:11-16, 2011.

• Preece M, Cayley PM, Scheuchl U, Lam RW: The relevance of an Employee Assistance Program to the treatment of workplace depression. Journal of Workplace Behavioral Health 21:67-77, 2005.

Treatment studies:

• Lam RW, Levitt AJ, Levitan RD, Michalak EE, et al. Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2016; 73:56-63.

• Vataire AL, Aballea S, Antonanzas F, Hakkaart-van Roijen L, Lam RW, McCrone P, Persson U, Toumi M: Core Discrete Event Simulation Model for the Evaluation of Health Care Technologies in Major Depressive Disorder. Value in Health 183-195 2014.

• Cheung A, Dewa C, Michalak EE, Browne G, Levitt A, Levitan RD, et al: Direct Health Care Costs of Treating Seasonal Affective Disorder: A Comparison of Light Therapy and Fluoxetine. Depression Research and Treatment, Article ID 628434, 2012.

• Murray G: Relief of Chronic or Resistant Depression (Re-ChORD): A pragmatic, randomized, open-treatment trial of an integrative program intervention for chronic depression. Journal of Affective Disorders 123:243-248, 2010.

• Parikh SV, Lam RW, Ovanessian MM, Filteau MJ, Hill M: Evaluation of a disease management intervention designed to reduce depression disability. Journal of Evaluation in Clinical Practice, 16:1-4, 2010.

• Hadjipavlou G, Lam RW: CANMAT Clinical Guidelines for the Management of Major Depressive Disorder in Adults: A Summary of Pharmacotherapy Recommendations. Mood & Anxiety Rounds, 2009.

Rating Scales:

• Lam RW, Michalak EE, Yatham LN: A new clinical rating scale for work absence and productivity: Validation in patients with major depressive disorder. BMC Psychiatry 9:78-84, 2009.

•  Iverson GL & Lam RW. Rapid screening for perceived cognitive impairment in major depressive disorder. Annals of Clinical Psychiatry 2013; 25:135.

 

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• Working with Depression: A clinical research program on workplace depression